Pentobarbital will decrease the level or effect of aprepitant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. pentobarbital will decrease the level or effect of quinine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. pentobarbital will decrease the level or effect of abiraterone by affecting hepatic/intestinal enzyme... https://wearethelist.com/story22380116/indicatori-sulla-pentobarbital-si-deve-sapere