There's a launch of norepinephrine from the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors within the dorsal horn to lower afferent pain transmission and develop analgesia. Therefore, medication like clonidine that focus on alpha-2 receptors can impact the transmission of discomfort. Applies to clonidine: oral tablet, oral tablet https://miltono592lrw6.wikicarrier.com/user