Environmental or self-antigens and homotypic interactions cause BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other alerts in the microenvironment and raising the activation of anti-apoptotic and proliferation pathways.31,32 Genomic studies have discovered recurrent mutations in genes regulating tumor mobile-microenvironment interactions, which ar... https://grahamt887iyo5.blogspothub.com/profile