Everyday living-threatening respiratory depression and Loss of life have happened in children who gained codeine. A lot of the noted circumstances happened following tonsillectomy and/or adenoidectomy and lots of of the children experienced proof of getting ultra-fast metabolizers of codeine due to a cytochrome P450 (CYP) 2D6 polymorphism (see WARNINGS, https://wockusa.com/product-category/codeine/